PURPOSE:We evaluated the hypothesis that induced perioperative hypothermia (32 ± 1ºC) affects the redox balance in the tissue of colonic anastomosis in rats by modifying biochemical enzymatic and non-enzymatic markers related to oxidative stress.METHODS:Forty-eight male Wistar rats were randomly divided into eight experimental groups of six animals each and underwent laparotomy, sigmoid section and immediate anastomosis. Four groups were operated under normothermia (36 ± 1ºC), and the other four under hypothermia (32 ± 1ºC). The animals were reoperated on days 3, 7 and 14 postoperatively, and two groups underwent SHAM at 3 days. From the scar tissue samples, the activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) was evaluated, and the levels of non-enzymatic markers of oxidative stress, such as reduced glutathione (GSH) and lipid peroxidation, were measured by the thiobarbituric acid reactive substances (TBARS) assay. The means were compared between groups corresponding to each day of sampling and euthanasia.RESULTS:The hypothermic groups showed a significant reduction on the activity of SOD on day 7 postoperatively, on the activity of CAT on days 7 and 14 postoperatively and on the levels of GSH on day 7 postoperatively. The level of lipid peroxidation was increased in the hypothermia group on day 7 postoperatively and decreased on day 14 compared with the normothermic groups.CONCLUSION:Perioperative hypothermia reduced the activity of the antioxidant enzymes catalase and superoxide dismutase, glutathione levels and increased lipid peroxidation in the scar tissue of colonic anastomoses in rats.

A colite cística profunda consiste na presença de cistos submucosos, contendo muco, principalmente no reto e no cólon esquerdo. De etiologia controversa, com pouco mais de 200 casos relatados na literatura mundial. Tem importância pela capacidade de mimetizar neoplasia maligna colorretal. Descreveremos um caso de colite cística profunda localizada no reto e submetida a tratamento cirúrgico, seu acompanhamento pós-operatório e revisão da literatura.

Colitis cystica profunda comprises submucous mucus-filled cysts, located mainly in rectum and left colon. Its etiology is controversial, with about 200 cases reported in the literature. This disease is important clinically in that mimics colorectal malignancies. We report a case of colitis cystica profunda localized in rectum treated surgically, its follow-up and review of the literature.